ABSTRACT
Objective:To determine the prevalence of Xerostomia in apparently healthy individuals
Methodology:This prospective cross sectional study was conducted on persons accompanying the patients at Medical and Dental OPD of Muhammad Medical College, Mirpurkhas in collaboration with Liaquat University of Health Sciences [LUMHS] Jamshoro from January 2016 to July 2016. 156 patients visited and the accompanying persons were 3015. Only adults were included and 915 patients consented to participate. Standardized questionnaire regarding demographic details, systemic diseases, use of drugs, and cigarette smoking was filled. Fox questionnaire was used to confirm Xerostomia. The data collected was analyzed by SPSS version 22. Qualitative variables were expressed as number and in percentage
Results: Among nine hundred and fifteen participants, age range was 21-65 years. The mean age was 47+/-7.6years,
those above 30 years were 813 [88.9%], whereas under 30years were 102 [11.1%]. Xerostomia was more common in persons above 30 years and difference between two age groups was statistically significant. In our study, 317
[34.6%] gave history of tobacco consumption as cigarettes or gutka or pan. Out of 915 patients, 508 [55.5%] had systemic diseases. Out of these 508 only 387 [76.1%] were taking medications. A significant association of Xerostomia
with drug intake was seen
Conclusion: The frequency of Xerostomia in apparently healthy subjects was high and alarming. Predisposing factors were age, female gender, systemic disease, use of drug and tobacco consumption.
ABSTRACT
Glycogen Storage Disease [GSD, also called Glycogenosis and Dextrinosis] is the result of defects in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. Patients usually present with low blood sugar, enlarged liver, slow growth, muscle cramps, seizures and anemia. Von Gierke disease is the most common type of glycogen storage disorder. Von Gierke[1] described the first patient with GSD type I in 1929 under the name hepatonephromegalia glycogenica. In 1952, Cori and Cori[2] demonstrated that glucose-6- phosphatase [G6Pase] deficiency was a cause of GSF type I. Other types are Pompe, Forbes, Con, Hers and Anderson types. GSD type 5 McArdle disease affects skeletal muscles[3]
ABSTRACT
OBJECTIVE: To find out the correlation between Chronic Idiopathic Urticaria and H.pylori infection and to observe the effect of Eradication therapy
STUDY DESIGN: Observational study
MATERIALS AND METHODS: 20 patients giving history of Chronic Idiopathic Urticaria were enrolled in the study. Serological testing for the presence of H. pylori infection done and were given eradication therapy [Capsule Esomeprazole 40 mg o.d, Tablet Metronidazole 400 mg t.d.s and Tablet Clarithromycin 500 mg b.i.d] for a period of 2 weeks. Clinical assessment was done at day 0, 30, 60, 90 and 120 by a scoring system [symptom evaluation scale], H.pylori status was reassessed at day 60 to confirm eradication effectiveness or to see any relapse of symptoms
SETTING: The study was conducted by the Department of Pharmacology and Therapeutics, BMSI, JPMC with the collaboration of Department of Dermatology JPMC Karachi from May 2008 to August 2008
RESULTS: Among 20 patients, 19 were positive for H.pylori infection and were given eradication therapy. Eradication therapy was successful in 18 patients one patient could not complete the study and there was relapse in one patient The mean SES scores decreased from 3.73 +/- 0.45 on day 0 to 2.52 +/- 0.51 on day 30, 1.52 +/-0.51 on day 60, 1.15 +/- 0.51 on days 90 and 0.47 +/- 0.77 on day 120. A percentage change of 59.13% was observed with a p value of <0.002
CONCLUSION: There is a possible role of H.pylori infection in pathogenesis of chronic idiopathic Urticaria